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Jeffrey M. Rosch, MD; George J. Pazin, MD; Philip Fireman, MD

JAMA. 1976;235(18):1995-1996.

Abstract
Amphotericin B in combination with mannitol was given to a patient who had mucocutaneous candidiasis and moderate renal insufficiency. Previously, amphotericin B alone had induced an abrupt increase in serum creatinine and urea nitrogen, but when mannitol was given concurrently there was no worsening of renal function. Thus, amphotericin B with mannitol appears to offer a less nephrotoxic but equally candicidal therapeutic regimen in the renal compromised patient requiring parenteral candicidal therapy.

(JAMA 235:1995-1996, 1976)

Author Affiliations
From the departments of pediatrics (Drs Rosch and Fireman) and medicine (Dr Pazin), University of Pittsburgh, and Children's Hospital, Pittsburgh.

Footnotes
Reprint requests to Children's Hospital, 125 Desota St, Pittsburgh, PA 15213 (Dr Fireman).

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