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Efficacy in Diagnosis of Endometrial Neoplasia

Leo B. Twiggs, MD; Philip J. DiSaia, MD; C. Paul Morrow, MD; Duane E. Townsend, MD; Charles E. Schwinn, MD

JAMA. 1976;235(25):2748-2750.

Abstract
The Gravlee jet irrigator was used in 556 women with abnormal uterine bleeding. The irrigator failed to demonstrate endometrial adenocarcinoma in 14 of 25 patients. In ten of these 14, the specimens were found to be unsatisfactory. Twenty-six percent (16 of 61) of those patients with unsatisfactory specimens had a proliferative endometrial lesion. The false-negative rate in diagnosing endometrial cancer with an adequate specimen was 27% (4 of 15). Forty-eight of 61 cases of hyperplastic endometrial lesions were not diagnosed by means of jet irrigation. The irrigation failed to detect premalignant endometrial lesions and was not sufficiently reliable to exclude endometrial carcinoma when a satisfactory negative specimen was obtained.

(JAMA 235:2748-2750, 1976)

Author Affiliations
From the Department of Obstetrics and Gynecology, Division of Gynecologic Oncology (Drs Twiggs, DiSaia, Morrow, and Townsend), and the departments of pathology (Dr Schwinn) and radiology-radiation therapy (Dr DiSaia), Los Angeles County—University of Southern California Medical Center, Los Angeles.

Footnotes
Reprint requests to Los Angeles County—University of Southern California Medical Center, Women's Hospital, 1240 N Mission Rd, Los Angeles, CA 90033 (Dr Twiggs).

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