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Edward B. Arenson, Jr, MD; John J. Hutter, Jr, MD; Robert D. Restuccia, MD; Charlene P. Holton, MD

JAMA. 1976;235(7):727-729.

Abstract
A growing literature supports the concept that some cases of neuroblastoma are hereditary. To this we add the first known case, to our knowledge, of neuroblastoma in a parent and child. Various factors, such as the remarkable tendency for this tumor to regress spontaneously, as well as its frequent fatal outcome, have reduced the number of observed familial cases. It is important that siblings and progeny of patients with neuroblastoma be examined to detect possible subclinical neuroblastoma.

(JAMA 235:727-729, 1976)

Author Affiliations
From the Department of Pediatrics, Ft Gordon Army Hospital, Ft Gordon, Ga (Dr Arenson), the Oncology Center (Drs Hutter and Holton), and Department of Pediatrics (Dr Restuccia), The Children's Hospital, and University of Colorado Medical Center (Dr Hutter), Denver. Dr Hutter is a Junior Faculty Clinical Fellow, American Cancer Society.

Footnotes
Reprint requests to Associate Director, Oncology Center, The Children's Hospital, 1056 E 19th Ave, Denver, CO 80218 (Dr Hutter).

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