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Hepatic Hemorrhage and Primary Hepatic Tumors

E. Truman Mays, MD; William M. Christopherson, MD; Merle M. Mahr, MD; Hugh C. Williams, MD

JAMA. 1976;235(7):730-732.

Abstract
Primary hepatic tumors developed in 13 young women who had been ingesting contraceptive steroids. Nine tumors were benign, and four malignant. Six tumors ruptured spontaneously and caused life-threatening hemorrhage. Benign tumors were successfully resected in eight women. One woman died during hepatic resection for malignant hepatoma; in two other cases of hepatocellular carcinoma, tumors were nonresectable. In two patients, the tumor was left in situ after neoplasm had been excluded by biopsy.

The increase of such tumors in women of childbearing age warrants the suspicion that these contraceptive steroid hormones play an etiologic role.

(JAMA 235:730-732, 1976)

Author Affiliations
From the departments of surgery (Drs Mays, Mahr, and Williams) and pathology (Dr Christopherson), University of Louisville School of Medicine, Louisville, and the Trover Clinic, Madisonville, Ky.

Footnotes
Read before the annual Clinical Congress of the American College of Surgeons, Miami, Fla, Oct 24, 1974.

Reprint requests to Department of Surgery, Albert B. Chandler Medical Center, University of Kentucky, Lexington, KY 40507 (Dr Mays).

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