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Examination by In Vivo Microscopy

Hildegard R. Maricq, MD; Maurice N. Johnson, MD; Charles L. Whetstone, MD; E. Carwile LeRoy, MD

JAMA. 1976;236(12):1368-1371.

Abstract
Examination by wide-field capillary microscopy of the hands of 152 workers in vinyl chloride (VC) polymerization plants demonstrated scattered, scleroderma-like microvascular abnormalities in 21 workers and isolated capillary abnormalities in 27, as compared with only three isolated abnormalities in 50 manual workers not exposed to vinyl chloride. Thirteen of 17 VC workers with objective evidence of VC-associated abnormalities (angiosarcoma or fibrosis of liver, acroosteolysis, or scleroderma-like skin lesions) were observed to have microvascular abnormalities.

If prospective studies confirm the implications of this study, capillary microscopy may become a useful mass-screening procedure in the early detection and prevention of VC-associated disease.

(JAMA 236:1368-1371, 1976)

Author Affiliations
From the Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston (Drs Maricq and LeRoy); The B. F. Goodrich Company, Akron, Ohio (Dr Johnson); and Continental Oil Company, Ponca City, Okla (Dr Whetstone).

Footnotes
Reprint requests to Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, 80 Barre St, Charleston, SC 29401 (Dr Maricq).

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