Chronic urticaria and intermittent anaphylaxis. Reactions to lophendylate
P. Lieberman, R. L. Siegle, R. J. Kaplan and K. Hashimoto
In a case of chronic, severe urticaria and intermittent episodes of
anaphylaxis due to an iophendylate injection (Pantopaque) given in the
course of myelography, almost complete relief was obtained from the removal
of approximately 8 ml of residual iophendylate from the spinal canal. Data
obtained from direct skin testing, Prausnitz-Kustner testing, peptide
inhibition of Prausnitz-Kustner testing, and IgE levels quantitated before
and after removal of iophendylate indicate that these symptoms were
mediated via an IgE anti-iophendylate reaction.
