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Effect on Adrenal Function After Substitution for Oral Glucocorticosteroids

Ernesto Bondarevsky, MD; Menachem S. Shapiro, MD; George Schey, MD; Joshua Shahor, MD; Israel Bruderman, MD

JAMA. 1976;236(17):1969-1971.

Abstract
The clinical effectiveness of beclomethasone dipropionate (BDP) aerosol and adrenal function after withdrawal of oral corticosteroid therapy were evaluated in 32 severely steroid-dependent asthmatic patients. Twenty-four of 28 patients were able to discontinue oral glucocorticosteroid therapy, while four failed to do so. Ventilatory studies showed no substantial changes at the end of six months' BDP treatment. In 24 patients, adrenal insufficiency was present before BDP therapy was started. In 20 of those patients, the response to cosyntropin returned to normal two months after discontinuation of systemic steroid treatment and administration of BDP.

(JAMA 236:1969-1971, 1976)

Author Affiliations
From the Department of Chest Disease (Drs Bondarevsky, Schey, Shahor, and Bruderman) and Medical Department C (Dr Shapiro), Meir Hospital, Kfar Saba, and the Sackler School of Medicine, University of Tel Aviv, Tel Aviv, Israel.

Footnotes
Reprint requests to Chest Department and Pulmonary Research Laboratory, Meir General Hospital, Kfar-Saba, Israel (Dr Bruderman).

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