Tyrosine-induced eye and skin lesions. A treatable genetic disease
L. A. Goldsmith and J. Reed
Tyrosine-induced eye and skin lesions in man are an autosomal, recessive,
inherited syndrome associated with tyrosinemia, tyrosinuria, and increased
urinary excretion of tyrosine metabolites. Patients have mild to severe
keratitis and erosive and hyperkeratotic lesions on the palms and soles.
The degree of involvement was variable in the small number of patients
studied. Mental retardation is frequently a part of the syndrome. A
low-tyrosine low-phenylalanine diet lowers blood tyrosine level and leads
to healing of the skin and eye lesions. Early dietary treatment may prevent
mental retardation.
