This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Survival in Severe Cardiopulmonary Disease

Paul Kasnitz, MD; George L. Druger, MD; Frederick Yorra, MD; Daniel H. Simmons, MD

JAMA. 1976;236(6):570-574.

Abstract
Mixed venous oxygen tension (P[unk]o₂), cardiac output ([unk]), and arterial oxygen tension (Pao₂) were measured in 20 patients with severe cardiac or pulmonary disease or both to determine which of these variables would best predict hyperlactatemia and survival. There was no correlation between Pao₂ and either hyperlactatemia or survival, possibly because all oxygen tensions were greater than 40 mm Hg. There was a good correlation between [unk] and both hyperlactatemia and survival, and a slightly better correlation between P[unk]o₂ and both hyperlactatemia and survival. Mixed venous oxygen tension, a reflection of both Pao₂ and [unk] was a better predictor of hyperlactatemia and death than either arterial Pao₂ or [unk] alone. It is also more easily measured and, therefore, more clinically useful than either [unk], as a predictor of anaerobiosis and survival, or blood lactate concentration, as a predictor of survival. A mixed venous oxygen tension below 28 mm Hg was usually associated with hyperlactatemia and was always associated with death.

(JAMA 236:570-574, 1976)

Author Affiliations
From the Division of Pulmonary Disease, Department of Medicine, UCLA School of Medicine, Los Angeles.

Footnotes
Read in part before the annual meeting of The American Thoracic Society, Montreal, May 19, 1975.

Reprint requests to Department of Medicine, UCLA School of Medicine, Los Angeles, 90024 (Dr Simmons).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Clinical Utility of B-Type Natriuretic Peptide in Early Severe Sepsis and Septic Shock
Rivers et al.
J Intensive Care Med 2007;22:363-373.
ABSTRACT  

Optimal hemoglobin concentration and high altitude: a theoretical approach for Andean men at rest
Villafuerte et al.
J. Appl. Physiol. 2004;96:1581-1588.
ABSTRACT | FULL TEXT  

CHRONIC NONPULSATILE BLOOD FLOW. III. EFFECTS OF PUMP FLOW RATE ON OXYGEN TRANSPORT AND UTILIZATION IN CHRONIC NONPULSATILE BIVENTRICULAR BYPASS
Tominaga et al.
J. Thorac. Cardiovasc. Surg. 1996;111:863-872.
ABSTRACT | FULL TEXT  

Respiratory Monitoring
Tobin
JAMA 1990;264:244-251.
ABSTRACT  

Analytic Reviews : Hemodynamic Management of the Adult Respiratory Distress Syndrome
Courtney Broaddus et al.
J Intensive Care Med 1987;2:190-213.
ABSTRACT  

Continuous Mixed Venous Oximetry in Critically Ill Surgical Patients: 'High-Tech' Cost-effectiveness
Orlando
Arch Surg 1986;121:470-471.
ABSTRACT  

Mixed Venous Oxygen Saturation: Its Role in the Assessment of the Critically Ill Patient
Kandel and Aberman
Arch Intern Med 1983;143:1400-1402.
ABSTRACT  

Aspects of the Management of Shock
SHINE et al.
ANN INTERN MED 1980;93:723-734.
ABSTRACT