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Rubella Vaccine in Postpubertal WomenExperience in Western Washington State
John P. Fox, MD, PhD;
Helen S. Rainey;
Carrie E. Hall, MPH;
C. George Ray, MD;
Maria J. Patterson, PhD
JAMA. 1976;236(7):837-843.
Abstract
Nearly two thousand nonimmune, postpubertal females given rubella vaccine in western Washington state in 1970 to 1974 were followed up for acute reactions, inadvertent pregnancy onset, and (776 women) seroresponse. Low-level prevaccination immunity appears to explain most of the apparent vaccine failure (11.6%). The 27 vaccine-complicated pregnancies identified resulted in 17 apparently normal infants (nine from nonimmune mothers). The remaining ten were terminated by abortion (four in nonimmune women), but no abortus yielded rubella virus. Frequency of postvaccination complaints (largely joint-related) varied with age (higher in those over 25 years), with vaccine (higher after HPV-77-DE-5 than after Cendehill strain virus), with stage of menstrual cycle when vaccine was given, and with method of contraception.
(JAMA 236:837-843, 1976)
Author Affiliations
From the Department of Epidemiology and International Health, School of Public Health and Community Medicine, University of Washington, Seattle (Dr Fox, Ms Rainey, and Ms Hall), and the departments of laboratory medicine, microbiology, and pediatrics, School of Medicine, University of Washington, and Children's Orthopedic Hospital and Medical Center, Seattle (Drs Ray and Patterson). Dr Patterson is now with the Department of Microbiology, Michigan State University, Lansing.
Footnotes
Reprint requests to Department of Epidemiology (SC-36), School of Public Health, University of Washington, Seattle, WA 98195 (Dr Fox).
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ABSTRACT
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