You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT JAMA
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 237 No. 14, April 4, 1977 TABLE OF CONTENTS
  JAMA
  •  Online Features
  ORIGINAL CONTRIBUTIONS
 This Article
 •References
 •Full text PDF
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in JAMA
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati Add to Twitter What's this?

Oral Aminophylline Therapy

Increased Dosage Requirements in Children

Darwin E. Zaske, PharmD; Kenneth W. Miller, PhD; Edward L. Strem, MD; Sol Austrian, MD; Paul B. Johnson, MD

JAMA. 1977;237(14):1453-1455.


Abstract

While monitoring oral aminophylline (theophylline ethylenediamine) therapy, larger doses (milligrams per kilogram) were necessary for children than for adults to achieve similar therapeutic serum levels. The mean apparent theophylline clearance (ATC) determined in 59 children was significantly higher (P <.001) than determined in 114 adults (84.8 versus 51.4 ml/hr/kg). Additionally, the younger children (1 to 9 years) eliminated theophylline more rapidly than the older children (10 to 18 years) (93.8 versus 77.3 ml/hr/kg). When initiating continuous oral aminophylline therapy, dosage guidelines, based on the mean ATC calculated for each group, were predicted, and trough theophylline serum levels of 10µg/ml were obtained. The guidelines for aminophylline were 28.0, 23.2, and 15.6 mg/kg/day administered in four divided doses for the younger children, older children, and adults, respectively. Monitoring of serum levels is suggested to further individualize the patient's aminophylline therapy.

(JAMA 237:1453-1455, 1977)



Author Affiliations

From the Clinical Pharmacokinetics Lab, College of Pharmacy, University of Minnesota (Drs Miller and Zaske), and the University of Minnesota School of Medicine (Drs Strem, Austrian, and Johnson), Minneapolis; and the Pediatric Allergy Clinic, Department of Pediatrics (Drs Strem and Austrian) and the Pulmonary Division, Department of Internal Medicine (Dr Johnson), St Paul Ramsey Hospital, St Paul.


Footnotes

Read in part before the American Academy of Pediatrics, Section on Allergy, Washington, DC, Oct 20, 1975.

Reprint requests to St Paul Ramsey Hospital, 640 Jackson St, St Paul, MN 55101 (Dr Zaske).



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Sustained-Release Theophylline: Pharmacokinetic and Therapeutic Comparison of Two Preparations
Menendez et al.
Arch Pediatr Adolesc Med 1983;137:469-473.
ABSTRACT  

Massive Theophylline Overdose: Rapid Elimination by Charcoal Hemoperfusion
Ehlers et al.
JAMA 1978;240:474-475.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1977 American Medical Association. All Rights Reserved.