Prevention of hyaline membrane disease with plasminogen. A cooperative study

C. M. Ambrus, T. S. Choi, E. Cunnanan, B. Eisenberg, H. P. Staub, D. H. Weintraub, N. G. Courey, R. J. Patterson, H. Jockin, J. W. Pickren, I. D. Bross, O. S. Jung and J. L. Ambrus

In a double-blind, randomized study, 500 premature infants were treated with plasminogen or placebo intravenously within 60 minutes of birth. There was a substantial decrease in severe clinical respiratory distress, death caused by hyaline membrane disease, and total mortality in the plasminogen-treated infants as compared to the controls.

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