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An Open Comparison

Edward C. Senay, MD; Walter Dorus, MD; Pierre F. Renault, MD

JAMA. 1977;237(2):138-142.

Abstract
Heroin addicts were recruited for a 14-week open clinical comparison of methadone hydrochloride and methadyl acetate. Patients were randomly assigned to a methadyl acetate clinic in which methadyl acetate was dispensed to patients three times per week or to a methadone clinic in which methadone was dispensed six days per week. No statistically significant differences were observed between groups in retention rates, illicit drug use, employment rates, or arrest rates. The group treated with methadyl acetate had more dropouts in the first seven weeks than the second seven weeks: this pattern was reversed for the methadone-treated group. The differences were significant (P=.01). Spontaneously reported symptoms suggest that induction with methadyl acetate may be a more clinically variable phenomenon than induction with methadone. The reduction of number of clinic visits in the group treated with methadyl acetate was not a source of variance in treatment effectiveness.

(JAMA 237:138-142, 1977)

Author Affiliations
From the Department of Psychiatry, University of Chicago (Drs Senay and Dorus); the Division of Research, National Institute on Drug Abuse (Dr Renault); and the Illinois Drug Abuse Program (Drs Senay and Dorus).

Footnotes
Reprint requests to Department of Psychiatry, University of Chicago, 950 E 59th St, Chicago, IL 60637 (Dr Senay).

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