Spectinomycin-resistant Neisseria gonorrhoeae

C. Thornsberry, H. Jaffee, S. T. Brown, T. Edwards, J. W. Biddle and S. E. Thompson

Neisseria gonorrhoeae resistant to high levels of spectinomycin (more than 2,048 microng/ml), were isolated from specimens obtained from a patient with urethritis. The bacterial resistance to spectinomycin is probably due to ribosomal changes that are a result of a chromosomal mutation. If spectinomycin fails to cure gonorrhea, spectinomycin resistance should be considered.