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  Vol. 237 No. 23, June 6, 1977 TABLE OF CONTENTS
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Mikulicz Disease and Subsequent Lupus Erythematosus Development

Robert W. Romero, MD; Lee T. Nesbitt, Jr, MD; Herbert Ichinose, MD

JAMA. 1977;237(23):2507-2510.


Abstract

In a 12-year-old boy with clinical and histologic features of Mikulicz disease, systemic lupus erythematosus (SLE) developed two years later. Atrophic plaques and nodules in the skin along with substantial increase in salivary gland enlargement characterized the onset of SLE. There was lack of renal and joint manifestations, and no evidence of keratoconjunctivitis sicca or xerostomia was seen. Histopathologic changes in the skin lesions included mucinous infiltrates, chronic vasculitis, and dermal-epidermal junction findings typical of SLE. Direct immunofluorescence studies of skin lesions and normal-appearing skin showed granular deposition of immunoglobulins and complement at the dermal-epidermal junction zone. Level of anti-DNA antibodies was noticeably elevated, and the serum C3 value was depressed. The patient's response to systemic corticosteroid therapy was dramatic.

(JAMA 237:2507-2510, 1977)



Author Affiliations

From the Department of Dermatology, Louisiana State University Medical Center (Drs Romero and Nesbitt), and the Department of Pathology, Tulane University School of Medicine (Dr Ichinose), New Orleans.


Footnotes

Reprint requests to Department of Dermatology, Louisiana State University Medical Center, 1542 Tulane Ave, New Orleans, LA 70112 (Dr Romero).



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