Intoxication caused by interaction of chloramphenicol and phenytoin
J. Q. Rose, H. K. Choi, J. J. Schentag, W. R. Kinkel and W. J. Jusko
A patient with a brain tumor and seizures who was receiving maintenance
doses of phenytoin was given chloramphenicol on three occasions. Her
neurological status was both complicated and obscured by the reoccurrence
of phenytoin intoxication. Retrospective drug analysis showed a marked
elevation of serum concentrations of phenytoin during each course of
chloramphenicol.
