Thrombocytopenic purpura following iopanoic acid ingestion
J. K. Hysell, J. W. Hysell and J. M. Gray
A 48-year-old woman had severe symptomatic thrombocytopenia three times in
13 months. Each episode followed ingestion of iopanoic acid. The interval
between drug ingestion and onset of symptoms was 40, 12, and 8 hours.
Resolution to normal platelet counts occurred in 6, 5, and 8 days. The
third thrombocytopenic crisis occurred while the patient was receiving
maintenance steroid therapy, given because the initial diagnosis was
idiopathic thrombocytopenic purpura. Incubation of platelet-rich plasma
with the patient's serum caused platelet lysis if either the patient or the
donor serum obtained after ingestion of iopanoic acid was present in the
mixture.
