Hemodialysis in methyprylon overdose. Some pharmacokinetic considerations

A. S. Pancorbo, P. A. Palagi, J. J. Piecoro and H. D. Wilson

Serial measurements of serum methyprylon concentration were made in the case of a 14-year-old girl who ingested an overdose of the drug. Our data indicate that, in the presence of high plasma levels of the drug, much longer half-lives than the usually reported four hours may be observed. It is postulated that saturation kinetics may be a possible mechanism for this observation. The striking clinical improvement after six hours of hemodialysis demonstrated the efficacy of this mode of treatment in our patient.