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Effective Therapy and Recovery of Hypothalamo-Pituitary-Adrenal Function

D. Robert Webb, MD

JAMA. 1977;238(14):1508-1511.

Abstract
Beclomethasone dipropionate was administered by aerosol to 30 patients whose chronic bronchial asthma required oral corticosteroid therapy. During the initial 12 weeks of the trial, beclomethasone therapy could be discontinued in 12 of 16 patients in contrast to only one of 14 patients receiving the inert aerosol placebo. Patients receiving the placebo were then given beclomethasone, and prednisone therapy was discontinued in five more. During six months of observation, adrenal function improved and steroid toxic reactions decreased in patients in whom oral corticosteroid therapy had been discontinued. Beclomethasone aerosol was generally well-tolerated. Asymptomatic thrush developed in four patients and rhinitis developed in ten patients as prednisone therapy was discontinued.

(JAMA 238:1508-1511, 1977)

Author Affiliations
From the Department of Medicine, The Mason Clinic, Seattle.

Footnotes
Reprint requests to Department of Internal Medicine, The Mason Clinic, 1100 Ninth Ave, PO Box 900, Seattle, WA 98111 (Dr Webb).

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