Coproexamination for botulinal toxin and clostridium botulinum. A new procedure for laboratory diagnosis of botulism
V. R. Dowell Jr, L. M. McCroskey, C. L. Hatheway, G. L. Lombard, J. M. Hughes and M. H. Merson
Stool or serum specimens or both from 318 persons pertaining to 165
botulism investigations over a three-year period were examined. Botulinal
toxin was detected in stools of 19 of 56 patients and in sera of 20 of 60
patients with clinical botulism; it was not detected in specimens from 246
persons with an illness other than botulism or well contacts of patients.
Clostridium botulinum was identified in stools of 36 of 60 clinical
botulism patients and in four of 27 asymptomatic contacts of patients with
botulism victims, but not in stools of 65 persons not associated with
confirmed botulism. When stool and serum samples were examined,
confirmatory evidence was obtained for 72.9% of the botulism cases.
Detection of botulinal toxin or C botulinum in the stool of a persons
should be considered evidence supporting the clinical diagnosis of
botulism.
