Plasma high-density lipoprotein cholesterol level. Influence of risk factor intervention
S. B. Hulley, R. Cohen and G. Widdowson
Determinants of circulating high density lipoproteins (HDL) were sought in
301 men studied during a year of participation in a coronary prevention
program. Mean plasma HDL-cholesterol concentration rose by 2.8 mg/dl (6%)
in the group receiving multifactor intervention, but the change did not
differ significantly from that in the comparison group. Larger changes in
both directions were seen in many individuals. Multiple regression analysis
of these changes indicates that increased plasma HDL levels occur when
plasma triglyceride level is decreased, cigarette smoking is reduced, and
habitual alcohol intake is increased. Increases in the concentration of
HDL-cholesterol also tended to accompany adherence to the fat-controlled
diet, reduction in LDL-cholesterol level, and loss of body weight.
Conventional coronary prevention programs are unlikely to have an adverse
influence on this new, risk-lowering factor.
