Tissue persistence of gentamicin in man
J. J. Schentag, W. J. Jusko, M. E. Plaut, T. J. Cumbo, J. W. Vance and E. Abrutyn
A two-compartment pharmcokinetic model was used to caracterize serum
concentrations and to predict tissue accumulation of gentamicin in 47
treated patients. Postmortem tissues were obtained in six cases; in each
instance, tissues yielded the predicted amount of drug. Slow release of
tissue-bound gentamicin accounts for its prolonged retention in the body.
The two-compartment model adequately predicts gentamicin accumulation from
serum concentrations and explains why this antibiotic persists in serum and
urine.
