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A Possible Immune Complex Disorder

Arnold S. Bayer, MD; Argyrios N. Theofilopoulos, MD; Robert Eisenberg, MD; Sidney G. Friedman, MD; Lucien B. Guze, MD

JAMA. 1977;238(5):408-410.

Abstract
A thrombotic thrombocytopenic purpura (TTP)-like syndrome was the chief presenting feature in two patients with infective endocarditis. Clinical and laboratory aberrations of the syndrome were rapidly reversed by specific antimicrobial therapy. Hypocomplementemia and high levels of circulating immune complexes were detected initially in both patients. Because these returned to normal as the TTP syndrome abated, an immunopathologic mechanism may have been operative.

(JAMA 238:408-410, 1977)

Author Affiliations
From the Research and Medical Services, Wadsworth Veterans Administration Hospital Center, Los Angeles (Drs Bayer, Friedman, Guze); the Department of Medicine, Harbor General Hospital, Torrance, Calif (Drs Bayer and Guze); University of California at Los Angeles School of Medicine (Drs Bayer and Guze); and Scripps Clinic and Research Foundation, Department of Immunopathology, La Jolla, Calif (Drs Theofilopoulos and Eisenberg).

Footnotes
Reprint requests to Research and Medical Services, Veterans Administration, Wilshire and Sawtelle Blvds, Los Angeles, CA 90073 (Dr Bayer).

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