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Thyroid Uptake of Radioactive Iodine in Hyperthyroidism
Philip L. Hooper, MD;
Robert H. Caplan, MD
JAMA. 1977;238(5):411-413.
Abstract
We compared the 24-hour uptake of radioactive iodine (RAIU) in hyperthyroid patients diagnosed from 1970 to 1972 (Group A) and from 1975 to 1976 (Group B). Mean RAIU values in Group B decreased from those in Group A. In 1969 we lowered the normal range for the RAIU test to 0% to 24%, and used the new range for the diagnosis of hyperthyroidism in both groups of patients. The RAIU in Group B is within normal limits in 14% of the patients with Graves' disease and 80% of the patients with toxic nodular goiter (TNG).
This study demonstrates that in our geographic area, the 24-hour RAIU has become a poor test for the diagnosis of hyperthyroidism, particularly TNG. However, the test should be performed before radioactive iodine therapy because it is necessary in calculating the therapeutic dose.
(JAMA 238:411-413, 1977)
Author Affiliations
From the Department of Internal Medicine, Gundersen Clinic, Ltd, and the La Crosse Lutheran Hospital, La Crosse, Wis. Dr Hooper is now with the University of New Mexico, Albuquerque, NM.
Footnotes
Reprint requests to Department of Internal Medicine, Gundersen Clinic, Inc, 1836 South Ave, La Crosse, WI 54601 (Dr Caplan).
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