Quinidine-induced agranulocytosis
E. V. Eisner, R. M. Carr and A. R. MacKinney
In a 75-year-old man, agranulocytosis and septicemia developed after eight
weeks of quinidine sulfate therapy. An IgG antibody requiring the presence
of quinidine was shown by complement-dependent leukocytotoxicity and
leukoagglutination reactions. The antibody did not cross-react with quinine
and was active against WBCs obtained from normal subjects and from the
patient himself.
