Atypical pyoderma gangrenosum with leukemia
S. J. Lewis, M. B. Poh-Fitzpatrick and R. R. Walther
Pyoderma gangrenosum (PG) has been increasingly reported in association
with myeloproliferative disorders. Monoclonal gammaopathy, myeloma, myeloid
metaplasia, and polycythemia have all been found in association with PG.
Recently, seven cases of PG in association with leukemia have been
described: three cases with acute myeloblastic leukemia, two cases with
chronic myelogenous leukemia, one case with acute lymphoblastic leukemia,
and one case with acute leukemia of either plasma cell or myeloblast
origin. To these we add two cases of PG with acute myeloblastic leukemia.
These patients often have an atypical clinical presentation for PG, with
bullae and relatively superficial involvement obscuring the correct
diagnosis.
