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Marc H. Branchey, MD; J. Hillary Lee, PhD; Ramesh Amin, MD; George M. Simpson, MB, MRCP

JAMA. 1978;239(18):1860-1862.

Abstract
The efficacy and side effects of a low-potency neuroleptic, thioridazine hydrochloride, and those of a high-potency neuroleptic, fluphenazine hydrochloride, were compared in 30 elderly chronic schizophrenic patients. Through a crossover design, each patient received both drugs with an intervening washout period. Although both drugs produced a similar degree of improvement, their side effects differed. Fluphenazine caused slightly more extrapyramidal effects than thioridazine, though few occurred with use of either drug. Thioridazine caused weight gain, blood pressure decreases, and ECG changes. High-potency neuroleptic agents appear to be the drugs of choice for elderly schizophrenic patients.

(JAMA 239:1860-1862, 1978)

Author Affiliations
From the Department of Mental Hygiene, Rockland Research Institute, Orangeburg, NY.

Footnotes
Reprint requests to Department of Mental Hygiene, Rockland Research Institute, Orangeburg, NY 10962 (Dr Simpson).

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