This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (10)  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Dennis K. Galanakis, MD; Joseph Newman, MD; Donald Summers, MD

JAMA. 1978;239(18):1873-1874.

Abstract
Circulating anticoagulants are unusual in drug-induced syndromes. We evaluated the prolonged thrombin time of plasma from a patient with a procainamide-induced syndrome. This defect was shown to be due to a circulating anticoagulant that was not of fibrin or fibrinogen origin and that prolonged thrombin and reptilase clotting times of plasma. Subclinical doses of heparin sodium induced hemorrhagic manifestations in this patient. Following cessation of heparin therapy, the circulating anticoagulant persisted but the bleeding tendency abated. All clinical and laboratory manifestations of this syndrome abated gradually following cessation of procainamide therapy.

(JAMA 239:1873-1874, 1978)

Author Affiliations
From the Departments of Pathology and Medicine, Downstate Medical Center, State University of New York, Brooklyn.

Footnotes
Reprint requests to Department of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave, Brooklyn, NY 11203 (Dr Galanakis).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Fatal Hemorrhage in a Patient with an Acquired Inhibitor of Human Thrombin
Spada et al.
NEJM 1995;333:494-497.
FULL TEXT