Reversibility of severe bleomycin-induced pneumonitis
W. G. Brown, F. M. Hasan and R. A. Barbee
The use of bleomycin sulfate as an antineoplastic agent has been limited by
its substantial pulmonary toxic effects. The exact incidence and prognosis
of bleomycin-pneumonitis is unresolved. Although bleomycin pulmonary
toxicity is thought to be dose-related, recent reports have emphasized
severe reactions at low doses. Furthermore, severe pulmonary toxicity has
been suggested to be progressive, irreversible, and ultimately, fatal. We
report clinical, roentgenographic, and pathophysiologic recovery after
severe, bleomycin-induced pneumonitis.
