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Results in the Newborn Population of New England

Marvin L. Mitchell, MD; P. Reed Larsen, MD; Harvey L. Levy, MD; Ann J. E. Bennett; Morton A. Madoff, MD, MPH

JAMA. 1978;239(22):2348-2351.

Abstract
During the first year of operation, the New England Regional Hypothyroidism Screening Program determined the concentration of thyroxine (T₄) levels in dried blood on filter paper from 129,028 infants born in Connecticut, Maine, Massachusetts, New Hampshire, and Rhode Island. Specimens from approximately 3,800 neonates were found to have levels of T₄ below the lower limit of normal (<6.0 µg/dl) and were assayed for thyroidstimulating hormone (TSH) content. Levels of TSH were elevated (>20 µU/ml) in 31 infants, 23 of whom eventually proved to have unequivocal hypothyroidism. Based on these figures and including two hypothyroid infants who were not tested, the incidence of congenital hypothyroidism in the New England region is approximately 1:5,200 births. The estimation of T₄ values supplemented by measurement of TSH values on specimens with low T₄ values has proved to be a satisfactory approach to large-scale screening for congenital hypothyroidism.

(JAMA 239:2348-2351, 1978)

Author Affiliations
From the State Laboratory Institute (Drs Mitchell, Levy, and Madoff and Ms Bennett), Department of Public Health, Commonwealth of Massachusetts, and the Department of Medicine (Dr Larsen), Peter Bent Brigham Hospital and Harvard Medical School, Boston.

Footnotes
Reprint requests to State Laboratory Institute, 305 South St, Jamaica Plain, MA 02130 (Dr Mitchell).

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