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Larry K. Pickering, MD; Herbert L. DuPont, MD; Jorge Olarte, DSc

JAMA. 1978;239(9):853-854.

Abstract
Forty-two adults who had Shigella isolated from stool (26 symptomatic, 16 asymptomatic) received a single oral dose of tetracycline hydrochloride (2.5 g). Minimal inhibitory concentrations of the 42 isolates demonstrated that 41% were sensitive to tetracycline. Sixteen of 18 patients with diarrhea who had tetracycline-resistant Shigella and all eight patients with diarrhea who had tetracycline-sensitive Shigella were clinically well and had Shigella-negative stools 48 hours after therapy. Fifteen of 16 asymptomatic patients demonstrated clearing of Shigella from stool within 48 hours of therapy. Single-dose tetracycline therapy is effective in the treatment of Shigella regardless of clinical expression of illness or in vitro sensitive of the organism.

(JAMA 239:853-854, 1978)

Author Affiliations
From the Program in Infectious Diseases and Clinical Microbiology, University of Texas Medical School, Houston (Drs Pickering and DuPont), and the Hospital Infantil de Mexico, Mexico City (Dr Olarte).

Footnotes
Reprint requests to Program in Infectious Diseases and Clinical Microbiology, University of Texas Medical School, 6400 W Cullen St, Houston, TX 77030 (Dr Pickering).

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