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Marilyn A. Hruby, MD; Victoria Schauf, MD

JAMA. 1978;240(13):1355-1357.

Abstract
Nine episodes of a unique short-incubation form of hepatitis were observed during five years in six hemophilic children after infusion with commercial factor VIII concentrate prepared by two different manufacturers. Five patients with a single episode had no previous infusion for 14 months to 14 years. One patient with several episodes had no previous infusion for at least seven months preceding each episode. The illness was mild and self-limited. No seroconversions to cytomegalovirus, Epstein-Barr virus, toxoplasmosis, or hepatitis A virus occurred. Acute hepatitis B virus infection was also excluded. The findings suggest the presence of one or more non-A, non-B hepatitis agents associated with factor VIII concentrates.

(JAMA 240:1355-1357, 1978)

Author Affiliations
From the Division of Hematology, Children's Memorial Hospital, and the Department of Pediatrics, Northwestern University (Dr Hruby), and the Section of Infectious Disease, Department of Pediatrics, Abraham Lincoln School of Medicine, University of Illinois (Dr Schauf), Chicago.

Footnotes
Reprint requests to Division of Hematology, Children's Memorial Hospital, 2300 Children's Plaza, Chicago, IL 60614 (Dr Hruby).

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