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Bioactivity of Instant GlucoseFailure of Absorption Through Oral Mucosa
Robin R. Gunning, MD;
Alan J. Garber, MD, PhD
JAMA. 1978;240(15):1611-1612.
Abstract
The efficacy of instant glucose as a potential treatment for hypoglycemia was studied in normal volunteers, with therapeutic doses administered in the buccal cavity. 2-Tritiated glucose (50 µCi) was homogenized into each dose before use. Mean blood glucose and serum insulin concentrations were unaltered by instant glucose. Glucose absorption was less than 0.05 mg at any time, and total glucose absorbed was less than 0.1 mg. For comparison purposes, volunteers swallowed a dose of instant glucose. Approximately 88% of the dose was absorbed during a 30-minute interval. Blood glucose and insulin levels increased. Instant glucose appears to be of therapeutic value only if swallowed by fully conscious, hypoglycemic patients. It should not benefit unconscious patients because of its poor absorption through the buccal mucosa.
(JAMA 240:1611-1612, 1978)
Author Affiliations
From the Division of Endocrinology and Metabolism, Departments of Internal Medicine (Drs Gunning and Garber) and Cell Biology (Dr Garber), Baylor College of Medicine, Houston. Dr Gunning is now in private practice.
Footnotes
Reprint requests to Department of Internal Medicine, Baylor College of Medicine, Houston, TX 77030 (Dr Garber).
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