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A Serious Limitation to Therapy in Rheumatoid Arthritis

Paul B. Halverson, MD; Franklin Kozin, MD; Gerson C. Bernhard, MD; Allan L. Goldman, MD

JAMA. 1978;240(17):1870-1871.

Abstract
A retrospective study of penicillamine toxicity in 156 patients yielded a high incidence of toxic reaction (62%), necessitating discontinuation of the drug therapy in 36% of the patients. Of the total group, proteinuria occurred in 14%, hematologic toxic reaction in 11%, mucocutaneous toxic reaction in 28%, and gastrointestinal intolerance in 12%.

(JAMA 240:1870-1871, 1978)

Author Affiliations
From the Department of Medicine, Rheumatology Section, The Medical College of Wisconsin, Milwaukee.

Footnotes
Reprints not available.

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