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Susan MacKinnon, MD; James G. Kane, MD; Richard H. Parker, MD

JAMA. 1978;240(18):1982-1983.

Abstract
A false-positive latex agglutination test for cryptococcal antigen occurred in a patient with a cervical prevertebral abscess and vertebral osteomyelitis caused by Klebsiella pneumoniae. Using a commercial latex agglutination test kit, a cryptococcal antigen titer of 1:32 was found in the CSF, but no cryptococcal antigen was found when the CSF was retested at a reference laboratory. The false-positive test resulted in unnecessary therapy with amphotericin B and delay in appropriate diagnostic studies and therapy.

(JAMA 240:1982-1983, 1978)

Author Affiliations
From the Section of Infectious Diseases, Medical Service, Veterans Administration Hospital, Washington, DC.

Footnotes
Reprint requests to Section of Infectious Diseases, Medical Service, Veterans Administration Hospital, 50 Irving St NW, Washington, DC 20422 (Dr Parker).

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