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Minoxidil Treatment of Malignant HypertensionRecovery of Renal Function
Friedrich C. Luft, MD;
Richard Bloch, MD;
James J. Szwed, MD;
Carlene M. Grim, RN, MS;
Clarence E. Grim, MD
JAMA. 1978;240(18):1985-1987.
Abstract
We treated eight severely hypertensive, long-term hemodialysis patients who failed to respond to ultrafiltration or conventional medication with minoxidil rather than with bilateral nephrectomy. Control of blood pressure and relief of symptoms was achieved in all eight. In addition, three of the patients, who were all severely oliguric, recovered sufficient renal function to allow the discontinuation of dialysis. Two are presently doing well, while one died of causes unrelated to uremia or minoxidil therapy. We presently reserve bilateral nephrectomy for those hypertensive dialysis patients who are awaiting transplantation.
(JAMA 240:1985-1987, 1978)
Author Affiliations
From the Renal Section and the Specialized Center for Research-Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis.
Footnotes
Reprint requests to Fesler Hall 110, Indiana University Medical Center, 1100 W Michigan St, Indianapolis, IN 46202 (Dr Luft).
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