Gentamicin tissue accumulation and nephrotoxic reactions
J. J. Schentag, T. J. Cumbo, W. J. Jusko and M. E. Plaut
In 64 adults treated with gentamicin sulfate, peak and trough serum
concentrations rose gradually and declined in two phases after the final
dose. Seventeen patients experienced renal damage. The 17 patients had
greater amounts of gentamicin in tissues even after the first dose and
before any renal effects were noted. This pharmacokinetics analysis
provided evidence that patients who experience gentamicin-related
nephrotoxic effects while receiving recommended doses of gentamicin could
be distinguished from patients with no toxic effects because they
experienced abnormal tissue accumulation before detectable changes in renal
function occurred.
