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Elevated Levels in Adult Hypertensive Patients

Siang Y. Tan, MD; Robert H. Noth, MD; Patrick J. Mulrow, MD

JAMA. 1978;240(2):123-126.

Abstract
Plasma 11-deoxycorticosterone levels were manyfold elevated in three adult patients with hypertension and elevated urinary excretion levels of 17-ketosteroids but without Cushing's syndrome. Dexamethasone therapy resulted in suppression of these steroids and in improvement of blood pressure in two of the patients. A partial adrenal 11β-hydroxylase deficiency appears to best explain these findings.

(JAMA 240:123-126, 1978)

Author Affiliations
From the Department of Internal Medicine (Drs Tan and Mulrow), Medical College of Ohio, Toledo, and the Yale University School of Medicine (Dr Noth), New Haven, Conn.

Footnotes
Reprint requests to Department of Medicine, Medical College of Ohio, CS 10008, Toledo, OH 43699 (Dr Tan).

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