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John M. Wallace, MD; David P. Gill, MD

JAMA. 1978;240(25):2752-2753.

Abstract
In a patient with paraganglioma, severe hypertension due to high levels of plasma norepinephrine was easily controlled with prazosin hydrochloride, 6 to 8 mg/day for 19 days before surgery. A prolonged antihypertensive response to the first two 1-mg doses suggested the presence of pheochromocytoma. This experience dramatizes the remarkable effectiveness of prazosin as a postsynaptic -adrenergic receptor blocker and invites further trials of the drug for both the diagnosis and treatment of pheochromocytoma.

(JAMA 240:2752-2753, 1978)

Author Affiliations
From the Departments of Medicine and Pharmacology, The University of Texas Medical Branch, Galveston.

Footnotes
Reprint requests to Ziegler 103, University of Texas Medical Branch, Galveston, TX 77550 (Dr Wallace).

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