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  Vol. 240 No. 25, December 15, 1978 TABLE OF CONTENTS
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Prazosin in the Diagnosis and Treatment of Pheochromocytoma

John M. Wallace, MD; David P. Gill, MD

JAMA. 1978;240(25):2752-2753.


Abstract

In a patient with paraganglioma, severe hypertension due to high levels of plasma norepinephrine was easily controlled with prazosin hydrochloride, 6 to 8 mg/day for 19 days before surgery. A prolonged antihypertensive response to the first two 1-mg doses suggested the presence of pheochromocytoma. This experience dramatizes the remarkable effectiveness of prazosin as a postsynaptic {alpha}-adrenergic receptor blocker and invites further trials of the drug for both the diagnosis and treatment of pheochromocytoma.

(JAMA 240:2752-2753, 1978)



Author Affiliations

From the Departments of Medicine and Pharmacology, The University of Texas Medical Branch, Galveston.


Footnotes

Reprint requests to Ziegler 103, University of Texas Medical Branch, Galveston, TX 77550 (Dr Wallace).



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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

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