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Single-Sample Screening Technique to Rule Out Growth-Hormone Deficiency

Roger E. Johnsonbaugh, MD, PhD; David E. Bybee, MD; Leon P. Georges, MD

JAMA. 1978;240(7):664-666.

Abstract
Parent-directed vigorous exercise was evaluated as a screening test for adequacy of pituitary growth-hormone release in 57 short-statured children. This method obviated the need for pharmacologic provocative testing in all but the four children with growth-hormone deficiency. In 92% of the euendocrine children, the immediate postexercise venous sample demonstrated an adequate growth-hormone level. Vigorous physical exercise after an 8- to 12-hour fast with a single postexercise serum growth-hormone sample is a reliable, safe, and cost-effective screening test for growth-hormone deficiency.

(JAMA 240:664-666, 1978)

Author Affiliations
From the Departments of Pediatrics (Dr Johnsonbaugh) and Medicine (Drs Bybee and Georges), National Naval Medical Center, and Uniformed Services University of the Health Sciences, Bethesda, Md.

Footnotes
The views expressed herein are those of the authors and do not necessarily reflect the views of the Navy Department or the Department of Defense.

Reprint requests to Department of Pediatrics, National Naval Medical Center, Bethesda, MD 20014 (Dr Johnsonbaugh).

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ABSTRACT