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Treatment of Acute Intermittent Porphyria With Large Doses of Propranolol
Dan Douer, MD;
Abraham Weinberger, MD;
Jack Pinkhas, MD;
Abraham Atsmon, MD, PhD
JAMA. 1978;240(8):766-768.
Abstract
A patient had an acute attack of intermittent porphyria with severe neurologic manifestations, hypertension, and tachycardia. Treatment with propranolol hydrochloride (Deralin [Israel]; Inderal, comparable US product) intravenously administered in a total dose of 284 mg during a period of 18 hours, was followed by clinical remission associated with a decline in urinary excretion of porphyrin precursors.
(JAMA 240:766-768, 1978)
Author Affiliations
From the Department of Internal Medicine D (Drs Douer, Pinkhas, and Weinberger) and the Laboratory of Biochemical Pharmacology (Dr Atsmon), Beilinson Medical Center, Petah Tiqva, Israel, and Tel Aviv University Medical School (Drs Douer, Weinberger, Pinkhas, and Atsmon), Ramat Aviv, Israel.
Footnotes
Reprint requests to Department of Internal Medicine D, Beilinson Hospital, Petah Tiqva, Israel (Dr Pinkhas).
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