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Combined Surgical, Radiation, and Lomustine Therapy

Fred H. Hochberg, MD; Rita Linggood, MD; Lynda Wolfson; William H. Baker, MD; Paul Kornblith, MD

JAMA. 1979;241(10):1016-1018.

Abstract
A retrospective evaluation of the quality and length of survival of 74 patients nonrandomly receiving lomustine, 100 to 110 mg/sq m, following craniotomy and irradiation for glioblastoma multiforme was performed. After surgery all patients were capable of at least partial self-care. Patients receiving postoperative irradiation and lomustine had a median survival of 11.5 months. While receiving chemotherapy, 40% of these patients were capable of at least partial employment; 75% were able to care for themselves. These levels of function were stable for 70% of the average postoperative course (8.0 months), following which a decline ensued.

(JAMA 241:1016-1018, 1979)

Author Affiliations
From the Departments of Neurology (Dr Hochberg and Ms Wolfson), Radiation Therapy (Dr Linggood), Medical Services (Dr Baker), and Neurosurgery (Dr Kornblith), Massachusetts General Hospital, Boston.

Footnotes
Reprint requests to Department of Neurology, Massachusetts General Hospital, Boston, MA 02114 (Dr Hochberg).

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