Serum lithium levels and long-term diuretic use
J. W. Jefferson and N. H. Kalin
In normal volunteers whose conditions were stablized with lithium
carbonate, there were no significant changes in serum lithium levels during
a two-week period while they received 40 mg/day of furosemide. During
another two-week period, a 50 mg/day dosage of hydrochlorothiazide did
cause a significant rise in serum lithium levels. These observations
suggest that a substantial amount of lithium and a loop diuretic may not
require modification of the lithium dosage.
