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Calcium and Parathyroid Disorders in ChildrenChronic Renal Failure and Treatment With Calcitriol
James C. M. Chan, MD;
Hector R. DeLuca, PhD
JAMA. 1979;241(12):1242-1244.
Abstract
Progression of renal failure, represented by rising serum creatinine concentrations, was correlated with progressive elevation of serum parathyroid hormone (PTH) concentrations in 23 children. A significant linear relationship was established. Despite normal serum calcium concentrations in 11 children receiving maintenance hemodialysis, circulating PTH concentrations were elevated after six months. Progressive deterioration with time occurred in all variables tested, at six-month intervals. These complications were reversible with kidney transplantation or treatment with 0.25 to 2 µg/day of calcitriol for four to 20 weeks.
(JAMA 241:1242-1244, 1979)
Author Affiliations
From the Nephrology Section, Department of Pediatrics, Medical College of Virginia, Health Sciences Division, Virginia Commonwealth University, Richmond (Dr Chan); and the Department of Biochemistry, College of Agriculture and Life Sciences, University of Wisconsin, Madison (Dr DeLuca).
Footnotes
Reprint requests to Box 822, MCV Station, Richmond, VA 23298 (Dr Chan).
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