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Thomas J. Lawley, MD; Kenneth C. Hertz, MD; Thomas R. Wade, MD; A. Bernard Ackerman, MD; Stephen I. Katz, MD, PhD

JAMA. 1979;241(16):1696-1699.

Abstract
We report an intensely pruritic cutaneous eruption that occurs in the third trimester of pregnancy. The clinical manifestations include erythematous urticarial papules and plaques that begin on the abdomen and spread to involve the thighs and occasionally the buttocks and arms. This dermatosis appears to be clinically distinct from previously described pruritic eruptions occurring in pregnancy. Biopsy specimens of the lesions show two histological patterns. We propose that this entity be termed "pruritic urticarial papules and plaques of pregnancy (PUPPP)."

(JAMA 241:1696-1699, 1979)

Author Affiliations
From the Dermatology Branch (Drs Lawley, Hertz, and Katz), National Cancer Institute, National Institutes of Health, Bethesda, Md, and the Departments of Dermatology (Drs Wade and Ackerman) and Pathology (Dr Ackerman), New York University School of Medicine, New York.

Footnotes
Reprint requests to Bldg 10, Room 12N238, National Institutes of Health, Bethesda, MD 20014 (Dr Lawley).

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