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Plasma Cell DyscrasiaAnalysis of 423 Patients
Albert I. Pick, MD;
Yehuda Shoenfeld, MD;
Rachel Frohlichmann;
Haya Weiss;
Debbora Vana;
Sarah Schreibman, MS
JAMA. 1979;241(21):2275-2278.
Abstract
Present clinical and laboratory diagnostic criteria permit a more accurate diagnosis and closer follow-up of patients with plasma cell dyscrasias. A ten-year follow-up of a group of 423 patients showed that the indications for and the adjustment of treatment are more precise when these criteria are summarized into profiles based on each diagnostic category. M components may be an indication of the presence of another sometimes nonreticular malignant neoplasm. The improvement of the specificity and sensitivity of immunologic methods sheds additional light on mechanisms controlling the synthesis of homogeneous antibodies such as prevalence of IgM- in mixed cryoglobulinemia and  -light chains in IgD myeloma, excretion of -Bence Jones proteins in amyloidosis, and greater IgG-subclass restriction in multiple myeloma as compared with benign monoclonal gammopathy. The activation of additional clones (biclonal gammopathies) was found in 3% of our patients.
(JAMA 241:2275-2278, 1979)
Author Affiliations
From the Section of Clinical and Tumor Immunology, The Rogoff Welcome Medical Institute, Beilinson Medical Center, Tel-Aviv University Medical School, Petah-Tikva, Israel.
Footnotes
Reprint requests to Beilinson Medical Center, Petah-Tikva, Israel (Dr Pick).
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