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Siang Y. Tan, MD; Ronald Shapiro, MD; Mary Ann Kish, MD

JAMA. 1979;241(25):2732-2733.

Abstract
Acute renal failure occurred during indomethacin therapy in a patient with chronic pyelonephritis. Urinary prostaglandin E₂ levels were diminished but returned to normal after discontinuation of drug therapy and recovery of renal function. Prostaglandins may be critical for the integrity of renal function, and the use of prostaglandin inhibitors such as indomethacin and other nonsteroidal anti-inflammatory drugs may be deleterious in patients with underlying renal disease.

(JAMA 241:2732-2733, 1979)

Author Affiliations
From the Division of Endocrinology and Metabolism and the Division of Nephrology, Department of Medicine, Medical College of Ohio, Toledo.

Footnotes
Reprint requests to Division of Nephrology, Department of Medicine, Medical College of Ohio, CS 10008, Toledo, OH 43699 (Dr Shapiro).

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