Severe anaphylactoid reaction to radiographic contrast media. Recurrences despites premedication with diphenhydramine and prednisone
J. S. Madowitz and M. J. Schweiger
Patients with a history of anaphylactoid reaction to radiographic contrast
medium (RCM) are at increased risk for subsequent reaction. To date, 275 of
these high-risk patients have been studied with use of prophylactic
pretreatment with diphenhydramine hydrochloride or prednisone or both
without a single severe anaphylactoid reaction on readministration of RCM.
This report describes a patient who received pretreatment as described in
the literature but suffered a life-threatening anaphylactoid reaction on
readministration of RCM. Premedication does not eliminate the possiblity of
a fatal reaction on readministration of RCM.
