Influenza vaccination in patients with rheumatic diseases. Safety and efficacy
A. Herron, G. Dettleff, B. Hixon, L. Brandwin, D. Ortbals, R. Hornick and B. Hahn
The safety and efficacy of influenza vaccination were studied in 32 healthy
volunteers and in 62 patients with systemic lupus erythematosus (SLE),
rheumatoid arthritis, degenerative joint disease, and other rheumatic
diseases. These individuals, none of whom was acutely ill, were examined at
the time of immunization and one week, three weeks, and four months later.
Flare-ups of rheumatic disease following immunization were infrequent and
usually minor. Seroconversion to A/New Jersey/76 developed in 62% to 87% of
all individuals and to A/Victoria/75 in 62% to 69%. Antibody responses to
A/New Jersey/76 were significantly lower in young patients taking
glucocorticoids compared to those not taking glucocorticoids. The antibody
responses to A/New Jersey/76 and A/Victoria/75 in patients with SLE were
not different from normal responses. Administration of these vaccines was
safe in these patients with stable disease and induced antibody responses
in most individuals.
Should children under treatment for juvenile idiopathic arthritis receive flu vaccination?
McCann
Arch. Dis. Child. 2007;92:366-368.
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Immunizing patients with systemic lupus erythematosus: a review of effectiveness and safety
O'Neill and Isenberg
Lupus 2006;15:778-783.
ABSTRACT
Safety and efficacy of influenza vaccination in systemic lupus erythematosus patients with quiescent disease
Holvast et al.
Ann Rheum Dis 2006;65:913-918.
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Vaccination against influenza in rheumatoid arthritis: the effect of disease modifying drugs, including TNF{alpha} blockers
Fomin et al.
Ann Rheum Dis 2006;65:191-194.
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Vaccinate your immunocompromised patients!
Gluck
Rheumatology (Oxford) 2006;45:9-10.
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Rheumatoid vasculitis following influenza vaccination
Iyngkaran et al.
Rheumatology (Oxford) 2003;42:907-909.
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Prophylactic use of antibiotics and immunisations in patients with SLE
Gilliland and Tsokos
Ann Rheum Dis 2002;61:191-192.
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Vaccination and systemic lupus erythematosus: the bidirectional dilemmas
Aron-Maor and Shoenfeld
Lupus 2001;10:237-240.
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Immunisation of patients with systemic lupus erythematosus: the current state of play
Ioannou and Isenberg
Lupus 1999;8:497-501.
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Use of Licensed Vaccines for Active Immunization of the Immunocompromised Host
Pirofski and Casadevall
Clin. Microbiol. Rev. 1998;11:1-26.
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