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Daria Kiani, MD; Edward L. Quinn, MD; Keith H. Burch, MD; Tom Madhavan, MD; Louis D. Saravolatz, MD; Thomas R. Neblett, PhD

JAMA. 1979;242(10):1044-1047.

Abstract
Polymicrobial bacteremia increased from 6% in 1970 to 13% in 1975 in patients with bloodstream infections. This type of serious infection most commonly complicated genitourinary (27%) and gastrointestinal (26%) conditions, frequently followed invasive procedures (68%), was more common in hospitalized patients (73%), and was often associated with malignancies (25%) or immunosuppressive or cancer chemotherapy (34%). Although polymicrobial endocarditis was more commonly encountered in recent years, this infection accounted for only 4.5% of patients with multiple organism bacteremias. Gram-negative aerobic bacteria were isolated from 62% and anaerobic bacteria in 39% of patients with polymicrobial bacteremia compared with 37% and 14%, respectively, in patients with monomicrobial bacteremia. In the 88 patients with polymicrobial bacteremia, the mortality was 44.5%, compared with 18.0% in patients with monomicrobial bacteremia.

(JAMA 242:1044-1047, 1979)

Author Affiliations
From the Division of Infectious Diseases, Department of Medicine (Drs Kiani, Quinn, Burch, Madhavan, and Saravolatz), and the Microbiology Division, Department of Pathology (Dr Neblett), Henry Ford Hospital, Detroit.

Footnotes
Reprint requests to Division of Infectious Diseases, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202 (Dr Quinn).

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